Lanolin

Drug Levels and Effects:




Summary of Use during Lactation:


Lanolin is a yellow fat obtained from sheep's wool. It has traditionally been used topically to treat sore, cracked nipples during breastfeeding. Highly purified modified lanolin (Lansinoh) has the pesticide and detergent residues removed and the natural free alcohols reduced to below 1.5% to improve safety and reduce the allergic potential.[1] Studies of lanolin, most of which used Lansinoh, for the prevention and treatment of nipple pain from breastfeeding have not found lanolin to be consistently different in efficacy from application of breastmilk, hydrogel dressings, peppermint gel, aloe vera or warm compresses.[2][3][4][5]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


In a randomized, double-bind trial, lanolin was compared to an all-purpose nipple ointment containing mupirocin 1%,betamethasone0.05%, and miconazole 2% for painful nipples while nursing in the first 2 weeks postpartum. The two treatments were equally effective in reducing nipple pain, nipple healing time, breastfeeding duration, breastfeeding exclusivity rate, mastitis and nipple symptoms, side effects or maternal satisfaction with treatment.[6]


References:


1. Mohammadzadeh A, Farhat A, Esmaeily H. The effect of breast milk and lanolin on sore nipples. Saudi Med J. 2005;26:1231-4. PMID:16127520
2. Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: a systematic review. J Obstet Gynecol Neonatal Nurs. 2005;34:428-37. PMID:16020410
3. Sayyah Melli M, Rashidi M R, Nokhoodchi A et al. A randomized trial of peppermint gel, lanolin ointment, and placebo gel to prevent nipple crack in primiparous breastfeeding women. Med Sci Monit. 2007;13:CR406-11. PMID:17767120
4. Abou-Dakn M, Fluhr JW, Mo G, Woeckel A. Positive effect of HPA lanolin versus expressed breastmilk on painful and damaged nipples during lactation. Skin Pharmacol Physiol. 2010;24:27-35. PMID:20720454
5. Tafazoli M, Saeedi R, Gholami Robatsangi M, Mazloom R. [Aloevera gel vs. lanolin ointment in the treatment of nipple sore: A randomized clinical trial]. Tehran Univ Med J. 2010;67:699-704.
6. Dennis CL, Schottle N, Hodnett E, McQueen K. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: A randomized controlled trial. Breastfeed Med. 2012. PMID:22428572



Substance Identification:




Substance Name:

Lanolin

CAS Registry Number:

8006-54-0

Drug Class:


  • Cosmetics

  • Pharmaceutic Aids

  • Waxes


  • Administrative Information:




    LactMed Record Number:


    927


    Last Revision Date:


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