Lansoprazole

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the use of lansoprazole during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


One case of elevated serum prolactin and galactorrhea was reported in a 21-year-old man. Whenomeprazolewas substituted for lansoprazole, the serum prolactin decreased to the normal range and galactorrhea ceased.[1]

A 13-year-old girl with a recent history of bilateral galactorrhea and hyperprolactinemia fromomeprazoleand domperidone on separate occasions was given lansoprazole to prevent gastrointestinal irritation following intravenous diclofenac for a severe headache. After 3 days of lansoprazole therapy, she again developed galactorrhea and an elevated serum prolactin that returned to normal a week after discontinuing lansoprazole.[2]


Alternate Drugs to Consider:


Cimetidine,Famotidine,Nizatidine,Omeprazole,Pantoprazole,Ranitidine,Sucralfate


References:


1. Izquierdo Prieto OM, Moreno Alia E, Rosillo Gonzalez A. [Galactorrhea induced by lansoprazole]. Aten Primaria. 2004;34:325-6. PMID:15491529
2. Jabbar A, Khan R, Farrukh SN. Hyperprolactinaemia induced by proton pump inhibitor. J Pak Med Assoc. 2010;60:689-90. PMID:20726208



Substance Identification:




Substance Name:

Lansoprazole

CAS Registry Number:

103577-45-3

Drug Class:


  • Anti-Ulcer Agents


  • Administrative Information:




    LactMed Record Number:


    411


    Last Revision Date:


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