Loperamide

Drug Levels and Effects:




Summary of Use during Lactation:


Use of loperamide during breastfeeding is unlikely to affect the infant.


Drug Levels:


Maternal Levels.

Loperamide has not been studied during breastfeeding, but the loperamide prodrug, loperamide oxide, has been studied in a dosage of 2 doses of 4 mg given 12 hours apart to 6 women 18 to 47 hours after delivery. Median loperamide milk concentrations were 0.18 mcg/L at 12 hours after the first dose, 0.27 mcg/L at 6 hours after the second dose, and 0.19 mcg/L at 24 hours after the second dose.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Nikodem VC, Hofmeyr GJ. Secretion of the antidiarrhoeal agent loperamide oxide in breast milk. Eur J Clin Pharmacol. 1992;42:695-6. PMID:1623917



Substance Identification:




Substance Name:

Loperamide

CAS Registry Number:

53179-11-6

Drug Class:


  • Antidiarrheals


  • Administrative Information:




    LactMed Record Number:


    424


    Last Revision Date:


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