Loxapine

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the use of loxapine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Loxapine can elevate serum prolactin.[2] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[3]

The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Alternate Drugs to Consider:


Haloperidol,Olanzapine


References:


1. Meltzer HY, Fang VS, Goode DJ. Prolactin and neuroleptics: clinical implications for efficacy and toxicity. The effect of neuroleptics and alpha-methyl-para-tyrosine on serum prolactin levels in laboratory animals and man. Psychopharmacol Bull. 1978;14:5-7. PMID:625539
2. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID:11913677



Substance Identification:




Substance Name:

Loxapine

CAS Registry Number:

1977-10-2

Drug Class:


  • Antipsychotic Agents


  • Administrative Information:




    LactMed Record Number:


    164


    Last Revision Date:


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