Meclizine

Drug Levels and Effects:




Summary of Use during Lactation:


Occasional doses of meclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to variousantihistaminesand drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to meclizine.[1]


Possible Effects on Lactation:


Antihistaminesin relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected byantihistaminepretreatment of postpartum mothers.[2] Whether lower oral doses ofantihistamineshave the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.


Alternate Drugs to Consider:


Dimenhydrinate


References:


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID:8498418
2. Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Investig . 1985;8:143-6. PMID:3928731
3. Pontiroli AE, De Castro e Silva E, Mazzoleni F, Alberetto M et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID:7228996



Substance Identification:




Substance Name:

Meclizine

CAS Registry Number:

569-65-3

Drug Class:


  • Antiemetics

  • Antihistamines
  • Anti-Allergic Agents


  • Administrative Information:




    LactMed Record Number:


    553


    Last Revision Date:


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