Drug Levels and Effects:

Summary of Use during Lactation:

Milnacipranhas not been studied in nursing mothers and the manufacturer recommends that nursing mothers not take milnacipran .[1] Because no information is available on the use of milnacipran during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels:

Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Galactorrhea is reported by the manufacturer to be a side effect of milnacipran .[1] One woman who was being treated for depression took an intentional overdose of 950 mg of milnacipran orally. From day 5 to day 15 after the overdose, the patient noted a flow of milk from her left breast. The galactorrhea resolved without treatment.[2]

In a study of cases of hyperprolactinemia and its symptoms (e.g., gynecomastia) reported to a French pharmacovigilance center, milnacipran was not found to have an increased risk of causing hyperprolactinemia compared to other drugs.[3]

Alternate Drugs to Consider:



1. Savella package insert. Forest Pharmaceuticals, Inc. January 2009.
2. de Haro L, Hayek-Lanthois M, Rodor F, Valli M . [Amenorrhea and galactorrhea after acute overdose with milnacipran ]. Therapie. 2001;56:799-800. PMID:11878113
3. Trenque T, Herlem E, Auriche P, Drame M. Serotonin reuptake inhibitors and hyperprolactinaemia: a case/non-case study in the French pharmacovigilance database. Drug Saf. 2011;34:1161-6. PMID:22077504

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Adrenergic Uptake Inhibitors

  • Antidepressive Agents

  • Serotonin Uptake Inhibitors

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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