Naloxone

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the excretion of naloxone into breastmilk. Because it is not orally bioavailable, it is unlikely to affect the breastfed infant. Studies in nursing mothers have shown that naloxone does not affect lactation hormone levels. If naloxone is required by the mother, it is not a reason to discontinue breastfeeding.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


In contrast to its effect in some animal species, naloxone does not affect suckling-induced secretion of oxytocin or prolactin in postpartum women.[1][2]


Alternate Drugs to Consider:


Naltrexone


References:


1. Cholst IN, Wardlaw SL, Newman CB, Frantz AG. Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids. Am J Obstet Gynecol. 1984;150:558-61. PMID:6496587
2. Johnson MR, Andrews MA, Seckl JR, Lightman SL. Effect of naloxone on neurohypophyseal peptide responses to breast feeding and breast stimulation in man. Clin Endocrinol (Oxf). 1990;33:81-6. PMID:2401100



Substance Identification:




Substance Name:

Naloxone

CAS Registry Number:

465-65-6

Drug Class:


  • Narcotic Antagonists


  • Administrative Information:




    LactMed Record Number:


    778


    Last Revision Date:


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