Drug Levels and Effects:

Summary of Use during Lactation:

Based on limited data, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels:

Maternal Levels.

A woman who was 3 days postpartum received 60 mg of nimodipine orally every 4 hours. She had a peak milk nimodipine level of about 3.5 mcg/L 1 hour after a dose at steady-state. Milk levels from 1 hour before a dose (i.e., 3 hours after the previous dose) to simultaneously with a dose were less than 1 mcg/L.[1] Using the peak milk level data, the estimated maximum intake of an exclusively breastfed infant would be about 0.0009% of the maternal weight-adjusted dosage.

One woman who was 3 weeks postpartum was receiving nimodipine 2 mg per hour intravenously for 22 hours. The highest milk nimodipine concentration occurred 2 hours after completing the regimen and was 4.7 mcg/L. Four hours later the level had dropped to 0.63 mcg/L. It was estimated that a nursing infant would receive a maximum daily dosage of 0.092% of the mother's weight-adjusted dosage.[2]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.


1. Tonks AM. Nimodipine levels in breast milk. Aust N Z J Surg. 1995;65:693-4. PMID:7575306
2. Carcas AJ, Abad-Santos F, de Rosendo JM et al. Nimodipine transfer into human breast milk and cerebrospinal fluid. Ann Pharmacother. 1996;30:148-50. PMID:8835048

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Antihypertensive Agents

  • Calcium
  • Channel Blockers

  • Vasodilator Agents

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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