Norepinephrine

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use of norepinephrine during breastfeeding. Because of its poor oral bioavailability and short half-life, any norepinephrine in milk is unlikely to affect the infant. High intravenous doses of norepinephrine might reduce milk production or milk letdown.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information in nursing mothers was not found as of the revision date. Animal data indicate that norepinephrine can decrease serum prolactin and reduce milk production.[1] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


References:


1. Thomas GB, Cummins JT, Doughton BW et al. Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep. J Endocrinol. 1989;123:393-402. PMID:2607250



Substance Identification:




Substance Name:

Norepinephrine

CAS Registry Number:

51-41-2

Drug Class:


  • Adrenergic Agonists

  • Adrenergic Alpha-Agonists

  • Catecholamines

  • Sympathomimetics

  • Vasoconstrictor Agents


  • Administrative Information:




    LactMed Record Number:


    779


    Last Revision Date:


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