Pantoprazole

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that maternal pantoprazole doses of 40 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants.


Drug Levels:


Maternal Levels.

A mother who was 10 months postpartum and partially nursing her infant was given a single 40 mg dose of oral pantoprazole. Pantoprazole was detectable in milk only 2 and 4 hours after the dose with milk levels of 36 mcg/L and 24 mcg/L, respectively, at those times. It was not detectable (<10 mcg/L) in milk at 6, 8 and 24 hours after the dose. The authors estimated that a fully breastfed infant would receive 0.14% of the maternal weight-adjusted dosage.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Cimetidine,Famotidine,Nizatidine,Omeprazole,Ranitidine,Sucralfate


References:


1. Plante L, Ferron GM, Unruh M et al. Excretion of pantoprazole in human breast. J Reprod Med. 2004;49:825-7. PMID:15568407



Substance Identification:




Substance Name:

Pantoprazole

CAS Registry Number:

102625-70-7

Drug Class:


  • Anti-Ulcer Agents


  • Administrative Information:




    LactMed Record Number:


    409


    Last Revision Date:


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