Papaya

Drug Levels and Effects:




Summary of Use during Lactation:


Papaya (Carica papaya)fruitcontains the proteolytic enzymes papain and chymopapain before ripening, but they are not present in the ripefruit. Cooked, unripe papayafruithas been used orally as a galactogogue in India and Melanesia;[1][2][3] however, no scientifically valid clinical trials support this use. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[4] Papaya leaves, which contain papain and other enzymes, are also used in some products, but have no known lactation-related uses. No data exist on the excretion of any components of papaya into breastmilk or on the safety and efficacy of papaya in nursing mothers or infants. Papayafruitis "generally recognized as safe" (GRAS) as a food by the US Food and Drug Administration. Papaya also contains carotenoids and can improve beta-carotene and vitamin A status in nursing mothers.[5] Allergic reactions to papaya, such as asthma and skin rashes are not uncommon and cross reaction with other substances such as latex and kiwi have occurred. Those with allergies to papaya or cross reacting substances should avoid papaya.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Sayed NZ, Deo R, Mukundan U. Herbal remedies used by Warlis of Dahanu to induce lactation in nursing mothers. Indian J Tradit Knowl. 2007;6:602-5.
2. Bourdy G, Walter A. Maternity and medicinal plants in Vanuatu. I. The cycle of reproduction. J Ethnopharmacol. 1992;37:179-96. PMID:1453707
3. Rasiya Beegam A, Nayar TS. Plants used for natal healthcare in folk medicine of Kerala, India. Indian J Tradit Knowl. 2011;10:523-7.
4. The Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #9: use of galactogogues in initiating or augmenting the rate of maternal milk secretion (First revision January 2011). Breastfeed Med. 2011;6:41-9. PMID:21332371
5. Ncube TN, Greiner T, Malaba LC, Gebre-Medhin M. Supplementing lactating women with pureed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr. 2001;131:1497-502. PMID:11340106



Substance Identification:




Substance Name:

Papaya

Scientific Name:

Carica papaya

Drug Class:


  • Complementary Therapies

  • Food

  • Phytotherapy

  • Plants, Medicinal


  • Administrative Information:




    LactMed Record Number:


    962


    Last Revision Date:


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