Pentazocine

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the use of pentazocine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Pentazocine can increase serum prolactin.[1][2] However, the prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Alternate Drugs to Consider:


Acetaminophen,Ibuprofen,Morphine


References:


1. Manner T, Kanto J, Scheinin H et al. Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma. Pharmacol Toxicol. 1987;61:301-4. PMID:3438224
2. Rolandi E, Barreca T. Effects of two analgesic opiates (methadone and pentazocine) on the serum prolactin levels in breast cancer. Acta Endocrinol (Copenh). 1978;88:452-4. PMID:581016



Substance Identification:




Substance Name:

Pentazocine

CAS Registry Number:

359-83-1

Drug Class:


  • Analgesics, Opioid

  • Narcotics

  • Narcotic Antagonists

  • Opiates


  • Administrative Information:




    LactMed Record Number:


    380


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.