Pentobarbital

Drug Levels and Effects:




Summary of Use during Lactation:


Because there is little published experience with pentobarbital during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

A mother who was 4 days postpartum had taken pentobarbital 100 mg daily for 3 days. A milk level of 170 mcg/L was measured 19 hours after the previous dose.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Zaleplon,Zolpidem


References:


1. Horning MG, Stillwell WG, Nowlin J et al. Identification and quantification of drugs and drug metabolites in human breast milk using GC-MS-COM methods. Mod Probl Paediatr. 1975;15:73-9.



Substance Identification:




Substance Name:

Pentobarbital

CAS Registry Number:

76-74-4

Drug Class:


  • Barbiturates

  • Hypnotics and Sedatives

  • GABA
  • Modulators


  • Administrative Information:




    LactMed Record Number:


    503


    Last Revision Date:


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