Pentoxifylline

Drug Levels and Effects:




Summary of Use during Lactation:


Limited data indicate that pentoxifylline is poorly excreted into breastmilk. It would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.


Drug Levels:


Maternal Levels.

Five women who had been breastfeeding for at least 6 weeks received a single 400 mg oral dose of asustained-releaseform of pentoxifylline. The average total milk concentration of pentoxifylline plus its 3 active metabolites was 419 mcg/L at 2 hours after the dose and 982 mcg/L at 4 hours.[1] Using the peak milk level data from this study, an exclusively breastfed infant would receive an estimated maximum of 147 mcg/kg daily with this maternal dosage regimen or about 2% of the maternal weight-adjusted dosage.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Witter FR, Smith RV. The excretion of pentoxifylline and its metabolites into human breast milk. Am J Obstet Gynecol. 1985;151:1094-7. PMID:3985069



Substance Identification:




Substance Name:

Pentoxifylline

CAS Registry Number:

6493-05-6

Drug Class:


  • Hematologic Agents

  • Phosphodiesterase Inhibitors

  • Platelet Aggregation Inhibitors

  • Xanthines


  • Administrative Information:




    LactMed Record Number:


    504


    Last Revision Date:


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