Pimozide

Drug Levels and Effects:




Summary of Use during Lactation:


Because there is no published experience with pimozide during breastfeeding, other drugs are preferred.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Pimozide can cause hyperprolactinemia.[1][2] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[3]


Alternate Drugs to Consider:


Haloperidol


References:


1. Fiore L, Scapagnini U, Canonico PL. Effect of dihydroergocryptine and dihydroergocristine on cyclic AMP accumulation and prolactin release in vitro: evidence for a dopaminomimetic action. Horm Res. 1987;25:171-7. PMID:3032757
2. Delitala G, Masala A, Alagna S. Suppression of pimozide-induced prolaction secretion by piridoxine (vitamin B6). Biomedicine. 1977;27:190-2.
3. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID:11913677



Substance Identification:




Substance Name:

Pimozide

CAS Registry Number:

2062-78-4

Drug Class:


  • Antipsychotic Agents


  • Administrative Information:




    LactMed Record Number:


    214


    Last Revision Date:


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