Piperacillin and Tazobactam

Drug Levels and Effects:




Summary of Use during Lactation:


Although no information is available on the use ofpiperacillinandtazobactamduring breastfeeding, limited information indicates that maternal doses ofpiperacillinproduce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated.Piperacillinandtazobactamis acceptable to use during breastfeeding.


Drug Levels:


Maternal Levels.

No studies on the combination ofpiperacillinandtazobactamduring breastfeeding have been reported.Piperacillinin a dosage of 4 grams intravenously every 8 hours for 3 or more days was given to 8 women. Milk levels were measured after 2 subsequent doses. After the first dose, milk levels ranged from 0.49 to 1.5 mg/L in the 3 hours after the dose. After the second dose, milk levels ranged from 1.1 to 1.9 mg/L in the 3 hours after the dose. Peak milk levels occurred 2 to 3 hours after the dose.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Baier R, Wolnik L, Puppel H et al.Piperacillinconcentrations in milk and serum from lactating women. Proc ICAAC. 1982;203. Abstract 779.



Substance Identification:




Substance Name:

PiperacillinandTazobactam

CAS Registry Number:

157044-21-8

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Penicillins


  • Administrative Information:




    LactMed Record Number:


    216


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.