Piperacillin

Drug Levels and Effects:




Summary of Use during Lactation:


Piperacillin is acceptable to use during breastfeeding. Limited information indicates that maternal doses of piperacillin up to 12 grams daily produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported withpenicillins, but these effects have not been adequately evaluated.


Drug Levels:


Maternal Levels.

Piperacillin in a dosage of 4gintravenously every 8 hours for at least 3 days was given to 8 women. Milk levels were measured after 2 subsequent doses. After the first dose, milk levels ranged from 0.49 to 1.5 mg/L in the 3 hours after the dose. Afer the second dose, milk levels ranged from 1.1 to 1.9 mg/L in the 3 hours after the dose. Peak milk levels occurred 2 to 3 hours after the dose.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Baier R, Wolnik L, Puppel H et al. Piperacillin concentrations in milk and serum from lactating women. Proc ICAAC. 1982;203. Abstract 779.



Substance Identification:




Substance Name:

Piperacillin

CAS Registry Number:

61477-96-1

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Penicillins

    Administrative Information:




    LactMed Record Number:


    217


    Last Revision Date:


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