Pneumococcal Vaccines

Drug Levels and Effects:




Summary of Use during Lactation:


The Centers for Disease Control and Prevention and several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants and that breastfeeding is not a contraindication to pneumococcal vaccine. Breastfed infants should be vaccinated according to the routine recommended schedules.[1][2][3]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Limited data indicate that breastfeeding can enhance the response of the infant to certain vaccine antigens.[1][3][4]

Immunization of pregnant women with pneumococcal vaccine increased the specific secretory IgA content of milk and colostrum.[5][6][7][8][9][10] These antibodies in colostrum help inhibit epithelial adhesion of pneumococci to pharyngeal epithelial cells.[10] Some evidence of decreased pneumococcal disease has been found among breastfed infants of vaccinated mothers.[8] Infants breastfed for longer than 90 days have a better antibody response to some pneumococcal strains in the vaccine at 13 months of age than those breastfed less than 90 days.[11]


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60 (RR-2):1-64. PMID:21293327
2. Gruslin A, Steben M, Halperin et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet. 2009;105:187-91. PMID:19367691
3. Anon. Human milk. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009.
4. Pabst HF. Immunomodulation by breast-feeding. Pediatr Infect Dis J. 1997;16:991-5. PMID:9380478
5. Shahid NS, Steinhoff MC, Hoque SS et al. Serum, breast milk, and infant antibody after maternal immunisation with pneumococcal vaccine. Lancet. 1995;346:1252-7. PMID:7475716
6. Munoz FM, Englund JA, Cheesman CC et al. Maternal immunization with pneumococcalpolysaccharidevaccine in the thirdtrimester of gestation. Vaccine. 2002;20:826-37. PMID:11738746
7. Finn A, Zhang Q, Seymour L et al. Induction of functional secretory IgA responses in breast milk, by pneumococcal capsularpolysaccharides. J Infect Dis. 2002;186:1422-9. PMID:12404157
8. Lehmann D, Pomat WS, Riley ID et al. Studies of maternal immunisation with pneumococcalpolysaccharidevaccine in Papua New Guinea. Vaccine. 2003;21:3446-50. PMID:12850357
9. Obaro SK, Deubzer HE, Newman VO et al. Serotype-specific pneumococcal antibodies in breast milk of Gambian women immunized with a pneumococcalpolysaccharidevaccine during pregnancy. Pediatr Infect Dis J. 2004;23:1023-9. PMID:15545857
10. Deubzer HE, Obaro SK, Newman VO et al. Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae. J Infect Dis. 2004;190:1758-61. PMID:15499530
11. Silfverdal SA , Ekholm L, Bodin L. Breastfeeding enhances the antibody response to Hib and pneumococcal serotype 6B and 14 after vaccination with conjugate vaccines. Vaccine. 2006;25:1497-502. PMID:17097198



Substance Identification:




Substance Name:

Pneumococcal Vaccines

Drug Class:


  • Vaccines


  • Administrative Information:




    LactMed Record Number:


    220


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.