Pregabalin

Drug Levels and Effects:




Summary of Use during Lactation:


Very limited data indicate that amounts of pregabalin in breastmilk are low. If pregabalin is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

In one woman, the breastmilk pregabalin level was about equal to the maternal serum concentration.[1]

Infant Levels.

The breastfed infant of a woman who was taking pregabalin (dose not specified) as an anticonvulsant during pregnancy and breastfeeding had a pregabalin serum concentration of 429 mcg/L at 48 hours postpartum, which was about 8% of the mother's serum concentration. Some of the infant's serum concentration could have been derived from transplacental passage, because the pregabalin half-life in this and another newborn averaged 17 hours.[1]


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Ohman I, De Flon P, Tomson T.Pregabalinkinetics in the neonatal period, and during lactation. Epilepsia. 2011;52 (Suppl 6):249-50. Abstract p824.



Substance Identification:




Substance Name:

Pregabalin

CAS Registry Number:

148553-50-8

Drug Class:


  • Analgesics

  • Anticonvulsants


  • Administrative Information:




    LactMed Record Number:


    908


    Last Revision Date:


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