Primaquine

Drug Levels and Effects:




Summary of Use during Lactation:


No information is available on the use of primaquine during breastfeeding. If it is required, the mother and infant should be tested for G6PD deficiency before primaquine is given to a woman who is breastfeeding. It may be used in breastfeeding mothers and infants with normal G6PD levels.[1]

In general, very small amounts of antimalarial drugs are excreted in the breast milk of lactating women. Because the quantity of antimalarial drugs transferred in breast milk is insufficient to provide adequate protection against malaria, infants who require chemoprophylaxis must receive the recommended dosages of antimalarial drugs.[2]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Chloroquine,Mefloquine


References:


1. Shealy K. Chapter 7. International travel with infants and young children. In. Centers for Disease Control and Prevention. CDC Health Information for International Travel 2010. Atlanta: U.S. Department of Health and Human Services, Public Health Service. 2009. http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-7/travel-and-breastfeeding.aspx#1889
2. Arguin PM, Steele SF. Chapter 2. The pre-travel consultation. Malaria. In. Centers for Disease Control and Prevention. CDC Health Information for International Travel 2010. Atlanta: U.S. Department of Health and Human Services, Public Health Service. 2009. http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-2/malaria.aspx



Substance Identification:




Substance Name:

Primaquine

CAS Registry Number:

90-34-6

Drug Class:


  • Anti-Infective Agents

  • Antimalarials


  • Administrative Information:




    LactMed Record Number:


    801


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.