Promethazine

Drug Levels and Effects:




Summary of Use during Lactation:


Based on minimal excretion of other phenothiazine derivatives, it appears that occasional short-term use of promethazine for the treatment of nausea and vomiting poses little risk to the breastfed infant. With repeated doses, observe infants for excess sedation. Because promethazine can lower basal prolactin secretion, promethazine might interfere with the establishment of lactation if given in the early postpartum period. An antiemetic without a potent histamine blocking action is preferred in the newborn period.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Unlike most phenothiazines, promethazine usually causes a reduction in basal prolactin secretion in nonnursing women.[1][2] The effect on nursing mothers is not known, but promethazine might interfere with the establishment of lactation if given in the early postpartum period. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Alternate Drugs to Consider:


Prochlorperazine


References:


1. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID:3928731
2. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID:7228996



Substance Identification:




Substance Name:

Promethazine

CAS Registry Number:

60-87-7

Drug Class:


  • Antiemetics

  • Phenothiazines


  • Administrative Information:




    LactMed Record Number:


    228


    Last Revision Date:


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