Quinidine

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that maternal doses of quinidine up to 1.8 grams daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be carefully monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.


Drug Levels:


Maternal Levels.

In one case report, a quinidine milk level of 6.4 mg/L was reported 3 hours after a dose while taking 600 mg every 8 hours orally of a sustained-release quinidinesulfatepreparation (Quninidex). In the same patient, a random milk level of 8.2 mg/L was also measured.[1] Data from this case indicate that a breastfed infant would receive about 3 to 4% of the maternal weight-adjusted dosage of quinidine.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Hill LM, Malkasian GD Jr. The use of quinidinesulfatethroughout pregnancy. Obstet Gynecol. 1979;54:366-8. PMID:471380



Substance Identification:




Substance Name:

Quinidine

CAS Registry Number:

56-54-2

Drug Class:


  • Antiarrhythmics


  • Administrative Information:




    LactMed Record Number:


    235


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.