Quinine

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the low levels of quinine in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. The dosage in milk is far below those required to treat an infant for malaria.[1] However, quinine should not be used in mothers with an infant who is glucose-6-phosphate dehydrogenase deficient.[2]


Drug Levels:


Maternal Levels.

One old study measured quinine levels in the milk of 6 women at varying times after 2 to 3 doses of 300 or 640 mg of quinine.[3] Milk levels ranged from traces to 4.4 mg/L, with an average of about 0.8 mg/L. The time of peak milk levels varied from 1.5 to 6.4 hours after the dose.

An unpublished study found that milk levels approximated one-third of simultaneous plasma levels. The author estimated that an infant would receive 1.5-3 mg/day of quinine base with maternal treatment.[4]

One group of investigators studied 30 women who received quinine while breastfeeding intravenously or orally. Two publications reported data from the same group of women. In one paper, the milk levels reported after intravenous quinine appeared to be the levels following oral quinine and vice versa.[5] This was apparently corrected in the later publication which is summarized as follows: twenty-five women received quininesulfate600 mg every 8 hours orally for 7 days had random breastmilk quinine levels averaging 2.6 mg/L (range 0.5 to 3.6 mg/L). In 3 of the women who had just initiated lactation, colostrum levels were 0.4, 0.9 and 1.9 mg/L. Five women who received quinine dihydrochloride 10 mg/kg/day (8.3 mg/kg of quinine base) intravenously for 2 to 7 doses had random breastmilk quinine levels averaging 3.4 mg/L (range 0.5 to 8 mg/L).[6]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Chloroquine,Hydroxychloroquine


References:


1. Fulton B, Moore LL. Antiinfectives in breastmilk. Part II: sulfonamides, tetracyclines, macrolides, aminoglycosides and antimalarials. J Hum Lact. 1992;8:221-3. PMID:1288560
2. Mathew JL. Effect of maternal antibiotics on breast feeding infants. Postgrad Med J. 2004;80(942):196-200. PMID:15082839
3. Terwilliger WG, Hatcher RA. The elimination of morphine and quinine in human milk. Surg Gynecol Obstet. 1934;58:823-6.
4. White NJ. Clinical pharmacokinetics of antimalarial drugs. Clin Pharmacokinet. 1985;10:187-215. PMID:3893840
5. Phillips RE, Looareesuwan S, White NJ et al. Quinine pharmacokinetics and toxicity in pregnant and lactating women with falciparum malaria. Br J Clin Pharmacol. 1986;21:677-83. PMID:3527243
6. Looareesuwan S, White NJ, Silamut K et al. Quinine and severe falciparum malaria in late pregnancy. Acta Leiden. 1987;55:115-20. PMID:3321826



Substance Identification:




Substance Name:

Quinine

CAS Registry Number:

130-95-0

Drug Class:


  • Antimalarials


  • Administrative Information:




    LactMed Record Number:


    303


    Last Revision Date:


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