Drug Levels and Effects:

Summary of Use during Lactation:

One infant was breastfed, apparently without noticeable harm, following maternal intravitreal ranibizumab injections. Vascular endothelial growthfactor(VEGF) levels in breastmilk were not changed following the injection. Because the breast and neonatal intestine have VEGF receptors, some authors recommend use of intravitreal ranibizumab over bevacizumab, which does appear to depress milk VEGF levels.[1]

Drug Levels:

Maternal Levels.

A woman was given 3 intravitreal injections of bevacizumab for scar-associated choroidal neovascularization in her left eye. Vascular endothelial growthfactor(VEGF) was measured in serum and breastmilk. After the intravitreal injection of bevacizumab, the VEGF level in breastmilk decreased from 13.3 to 8.6 mcg/L over a 2-week period. After changing therapy to ranibizumab therapy, no decrement in breastmilk VEGF was seen during the 42 days following injection.[1]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.


Ehlken C, Martin G, Stahl A, Agostini HT. Reduction of vascular endothelial growthfactora in human breast milk after intravitreal injection of bevacizumab but not ranibizumab. Arch Ophthalmol. 2012;130:1226-7. PMID:22965611

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Antibodies, Monoclonal, Humanized

  • Angiogenesis Inhibitors

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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