Reserpine

Drug Levels and Effects:




Summary of Use during Lactation:


Because no information is available on the use of reserpine during breastfeeding and it might adversely affect the breastfed infant, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Although not well documented, reserpine is said to cause nasal stuffiness and increased tracheobronchial secretions in breastfed infants.[1]


Possible Effects on Lactation:


Reserpine has reportedly caused galactorrhea and has been used to increase breastmilk production, although it is obsolete for this use.[2][3][4]


Alternate Drugs to Consider:


Enalapril,Methyldopa,Nifedipine,Propranolol


References:


1. Knowles JA. Drugs in milk. Pediatr Currents. Ross Laboratories. 1972;21:28-32.
2. Vaidya RA, Vaidya AB, Van Woert MH et al. Galactorrhea and Parkinson-like syndrome: an adverse effect of alpha-methyldopa. Metabolism. 1970;19(12):1068-70. PMID:4923681
3. Mazhbits IA. [Use of reserpine as a lactogenic substance]. Akush Ginekol (Mosk). 1970;46(1):70-2. PMID:5433043
4. Somlyo AP, Wayde JD. Abnormal lactation. Report of a case induced by reserpine and a brief review of the subject. J Mt Sinai Hosp N Y. 1960;27(Jan-Feb):5-9. PMID:13832752



Substance Identification:




Substance Name:

Reserpine

CAS Registry Number:

50-55-5

Drug Class:


  • Antihypertensive Agents


  • Administrative Information:




    LactMed Record Number:


    239


    Last Revision Date:


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