Rituximab

Drug Levels and Effects:




Summary of Use during Lactation:


Rituximab is a large protein molecule with a molecular weight of 143,860. Only small amounts at most would be expected to enter breastmilk. No information is available on the use of rituximab during breastfeeding, so an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[1][2]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


(Rheumatoid Arthritis) Auranofin,GoldSodiumThiomalate,Hydroxychloroquine,Infliximab,Methotrexate,Penicillamine,Sulfasalazine


References:


1. Ostensen M. Management of early aggressive rheumatoid arthritis during pregnancy and lactation. Expert Opin Pharmacother. 2009;10:1469-79. PMID:19505214
2. Keeling SO, Oswald AE. Pregnancy and rheumatic disease: "by the book" or "by the doc". Clin Rheumatol. 2009;28:1-9. PMID:18987777



Substance Identification:




Substance Name:

Rituximab

CAS Registry Number:

174722-31-7

Drug Class:


  • Antirheumatic Agents


  • Administrative Information:




    LactMed Record Number:


    888


    Last Revision Date:


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