Secobarbital

Drug Levels and Effects:




Summary of Use during Lactation:


Because there is little published experience with secobarbital during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.


Drug Levels:


Maternal Levels.

Secobarbital was detected but not quantified 24 hours after an unspecified dose in a woman who was 4 days postpartum.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Secobarbital 200 mg given intravenously during labor 10 minutes to 3 hours before delivery for obstetric sedation reduced the sucking behavior of the newborn infants. The number of sucks, sucking pressure and total consumption of artificial feeding from the testing device were reduced substantially.[2]


Alternate Drugs to Consider:


Zaleplon,Zolpidem


References:


1. Horning MG, Stillwell WG, Nowlin J et al. Identification and quantification of drugs and drug metabolites in human breast milk using GC-MS-COM methods. Mod Probl Paediatr. 1975;15:73-9.
2. Kron RE, Stein M, Goddard KE. Newborn sucking behavior affected by obstetric sedation. Pediatrics. 1966;37:1012-6. PMID:5949020



Substance Identification:




Substance Name:

Secobarbital

CAS Registry Number:

76-73-3

Drug Class:


  • Barbiturates

  • Hypnotics and Sedatives

  • GABA
  • Modulators


  • Administrative Information:




    LactMed Record Number:


    509


    Last Revision Date:


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