Drug Levels and Effects:

Summary of Use during Lactation:

Because little information is available on the use of selegiline during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels:

Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

A woman took selegiline 10 mg/day,levodopa400 mg and benserazide 100 mg daily throughout pregnancy and continued them while breastfeeding her infant for 3 days. The child was followed for 10 years and no developmental abnormalities were found.[1]

Possible Effects on Lactation:

Selegiline can decrease serum prolactin in women with migraine,[2] and in those taking neuroleptic drugs with elevated serum prolactin.[3][4] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


1. Kupsch A, Oertel WH. Selegiline, pregnancy, and Parkinson's disease. Mov Disord. 1998;175-6. PMID:9452347
2. Calabresi P, Silvestrini M, Stratta F et al. l-Deprenyl test in migraine: neuroendocrinological aspects. Cephalalgia. 1993;13:406-9. PMID:8313454
3. Kodesh A, Weizman A, Aizenberg D et al. Selegiline in the treatment of sexual dysfunction in schizophrenic patients maintained on neuroleptics: a pilot study. Clin Neuropharmacol. 2003;26:193-5. PMID:12897639
4. Perenyi A, Bagdy G, Arato M. An early phase II trial with L-deprenyl for the treatment of neuroleptic-induced parkinsonism. Pharmacopsychiatria. 1983;16:143-6. PMID:6140692

Substance Identification:

Substance Name:


CAS Registry Number:


Drug Class:

  • Antiparkinson Agents

  • Monoamine Oxidase Inhibitors

  • Neuroprotective Agents

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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