Sodium Picosulfate

Drug Levels and Effects:




Summary of Use during Lactation:


Sodiumpicosulfate is not absorbed from the gastrointestinal tract, and its active metabolite, which is absorbed, is not detectable in breastmilk.Sodiumpicosulfate can be taken during breastfeeding and no special precautions are required.


Drug Levels:


Maternal Levels.

Sixteen postpartum women who were not breastfeeding, but were producing at least 200 mL of milk daily by breast pump were given either oral enteric-coated bisacodyl tablets (Dulcolax) 10 mg daily or oral liquidsodiumpicosulfate (Laxoberal) 10 mg daily for 7 days. Both drugs are prodrugs metabolized to the active drug, bis-(p-hydroxyphenyl)-2-pyridyl-2-methane (BHPM). All breastmilk was collected daily from the day before drug administration to 2 days after the last dose. Free and conjugated BHPM were undetectable (<1 mcg/L) in all milk samples.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Bisacodyl,Docusate,Magnesium Hydroxide,Psyllium,SodiumPhosphate


References:


1. Friedrich C , Richter E, Trommeshauser D et al. Lack of excretion of the active moiety of bisacodyl andsodiumpicosulfate into human breast milk: an open-label, parallel group, multiple dose study in healthy lactating women. Drug Metab Pharmacokinet. 2011;26:458-64. PMID:21697613



Substance Identification:




Substance Name:

SodiumPicosulfate

CAS Registry Number:

10040-45-6

Drug Class:


  • Cathartics

  • Gastrointestinal Agents


  • Administrative Information:




    LactMed Record Number:


    1006


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.