Sodium Stibogluconate

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that maternal doses ofsodiumstibogluconate up to 1.4 grams daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants,[1] especially if the infant is older than 2 months. However, if withholding nursing during therapy is elected, breastfeeding can be reinstituted 24 to 48 hours after the last dose.


Drug Levels:


Maternal Levels.

A nursing mother was given 1 dose ofsodiumstibogluconate 1 gram intravenously, followed by intravenous doses of 1.4 grams (about 20 mg/kg of antimony) daily for 14 days. Numerous milk samples were obtained before and for 25 hours after the fifth and fourteenth doses of the drug. The average of the 2 trough values of antimony in milk was 0.7 mg/L; the average of the 2 peak concentrations was 3.5 mg/L at 4 hours after the dose.[1] (For comparison, average background antimony breastmilk concentrations range from 0.14 to 0.4 mcg/L[2][3]). After thesodiumstibogluconate doses, milk antimony levels declined with a half-life of about 6 hours to a value of 0.7 mg/L at 23 hours after the dose.[1] Using the average of the peak and trough values, a fully breastfed infant would receive about 0.3 mg/kg daily of antimony or about 1.6% of the maternal weight-adjusted dosage.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Berman JD, Melby PC, Neva FA. Concentration of Pentostam in human breast milk. Trans R Soc Trop Med Hyg. 1989;83:784-5. PMID:2559511
2. Abdulrazzaq YM, Osman N, Nagelkerke N et al. Trace element composition of plasma and breast milk of well-nourished women. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008;43:329-34. PMID:18205064
3. Wappelhorst O, Kuhn I, Heidenreich H, Markert B. Transfer of selected elements from food into human milk. Nutrition. 2002;18:316-22. PMID:11934544



Substance Identification:




Substance Name:

SodiumStibogluconate

CAS Registry Number:

16037-91-5

Drug Class:


  • Antiinfective Agents

  • Antiprotozoal Agents


  • Administrative Information:




    LactMed Record Number:


    641


    Last Revision Date:


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