Taliglucerase alfa

Drug Levels and Effects:




Summary of Use during Lactation:


No data exist on the use of taliglucerasealfaduring breastfeeding. Because it is an enzyme, it is likely to be destroyed in the infant's gastrointestinal tract and not absorbed systemically.[1][2] A limited amount of data support the safety of breastfeeding with alglucerase (the placenta-derived form of the enzyme) and imiglucerase (another biosynthetic form of the enzyme). An international panel of clinicians from 9 centers that treat Gaucher's disease reported that, breastfeeding complications were less frequent in mothers who were treated with alglucerase or imiglucerase postpartum than in untreated mothers with Gaucher's disease. Consider limiting the duration of breastfeeding to about 6 months to avoid excessive bone loss in the nursing mother.[2][3]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Belmatoug N. Considerations for pregnant patients with Gaucher disease: challenges for the patient and physician. Clin Ther. 2009;31 (Suppl. C):S192-3.
2. Zimran A, Morris E, Mengel E et al. The female Gaucher patient: the impact of enzyme replacement therapy around key reproductive events (menstruation, pregnancy and menopause). Blood Cells Molec Dis. 2009;43:264-88. PMID:19502088
3. Granovsky-Grisaru S, Belmatoug N, vom Dahl S. The management of pregnancy in Gaucher disease. Eur J Obstet Gynecol Reprod Biol. 2011;156:3-8. PMID:21269752



Substance Identification:




Substance Name:

Taliglucerasealfa

CAS Registry Number:

37228-64-1

Drug Class:


  • Enzymes

  • Enzyme Replacement Therapy


  • Administrative Information:




    LactMed Record Number:


    997


    Last Revision Date:


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