Thiothixene

Drug Levels and Effects:




Summary of Use during Lactation:


Because there is no published experience with thiothixene during breastfeeding, other antipsychotic agents are preferred.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Thiothixenehas caused galactorrhea.[1] Hyperprolactinemia appears to be the cause of the galactorrhea.[2][3][4] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Alternate Drugs to Consider:


Haloperidol,Olanzapine,Risperidone


References:


1. Kahn JL. More on galactorrhea associated with molindone. Am J Psychiatry. 1979;136:1617-8. Letter. PMID:574364
2. Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972;130:349-54. PMID:4560178
3. Turkington RW. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972;34:62-6. PMID:5061776
4. Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976;33:279-86. PMID:1259521
5. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID:11913677



Substance Identification:




Substance Name:

Thiothixene

CAS Registry Number:

5591-45-7

Drug Class:


  • Antipsychotic Agents

  • Thioxanthines


  • Administrative Information:




    LactMed Record Number:


    256


    Last Revision Date:


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