Ticarcillin and Clavulanic Acid

Drug Levels and Effects:

Summary of Use during Lactation:

Although no information is available on the use of ticarcillin and clavulanicacidduring breastfeeding, limited information indicates that maternal doses of ticarcillin 15 grams daily produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated. The combination of ticarcillin and clavulanicacidis acceptable to use during breastfeeding.

Drug Levels:

Maternal Levels.

No studies on the combination of ticarcillin and clavulanicacidduring breastfeeding have been reported. Only trace levels of ticarcillin were detected for 6 hours after single 1 gram intramuscular doses in 3 women in one study[1][2] and 5 women in another early study.[3]

After ticarcillin doses of 5 grams intravenously three times a day in 10 women, milk levels averaged 2 to 2.5 mg/L. By 12 hours after the last dose, ticarcillin was undetectable in the milk. The total daily intake of a breastfed infant would be negligible.[4]

Infant Levels.

Relevant published information was not found as of the revision date.

Effects in Breastfed Infants:

Relevant published information was not found as of the revision date.

Possible Effects on Lactation:

Relevant published information was not found as of the revision date.


1. Matsuda S, Tanno M, Kashiwakura T et al. Laboratory and clinical use of ticarcillin. Chemotherapy (Tokyo). 1977;25:2924-31.
2. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID:6743732
3. Cho N, Nakayama T, Uehara K et al. Laboratory and clinical evaluation of ticarcillin in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1977;25:2911-23.
4. von Kobyletzki D, Dalhoff A, Lindemeyer H et al. Ticarcillin serum and tissue concentrations in gynecology and obstetrics. Infection. 1983;11:144-9. PMID:6885173

Substance Identification:

Substance Name:

Ticarcillin and ClavulanicAcid

CAS Registry Number:


Drug Class:

  • Antiinfective Agents

  • Antibacterial Agents

  • Penicillins

  • Administrative Information:

    LactMed Record Number:


    Last Revision Date:

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