Tinidazole

Drug Levels and Effects:




Summary of Use during Lactation:


Amounts of tinidazole in milk are less than doses given to infants. Measurements of infant plasma levels during breastfeeding have not been reported. No studies have evaluated adverse effects of tinidazole on the infant during breastfeeding, but presumably they are similar to those of the closely related drug, metronidazole, such as increased risk of oral and rectal

Candida

infections.

As with metronidazole, concern has been raised about exposure of healthy infants to tinidazole via breastmilk,[1] because of possible mutagenicity and carcinogenicity. Opinions vary among experts on the advisability of using tinidazole during longer-term therapy while breastfeeding, but avoidance of breastfeeding for 3 days after a single dose should allow milk levels to drop to negligible values.[2] Other drugs are available for some conditions that tinidazole is used to treat.


Drug Levels:


Maternal Levels.

Twenty-four women who delivered by cesarean section were given a single intravenous dose of tinidazole 500 mg after cord clamping. Colostrum levels of tinidazole averaged 5.8 mg/L at 12 hours after the dose, 3.5 mg/L at 24 hours, 1.2 mg/L at 48 hours and 0.3 mg/L at 72 hours after the dose. The drug was barely detectable 96 hours after the dose. Only slight differences existed between concentrations in fore- and hindmilk.[3]

Five women who delivered by cesarean section were given a single intravenous dose of tinidazole 1600 mg after cord clamping. Milk concentrations and volumes were measured for 96 hours after the dose. The authors concluded that milk concentrations would be sufficiently low to commence breastfeeding 72 hours after the dose.[4]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


(Anaerobic bacterial infections)Amoxicillinand Clavulanic Acid,Clindamycin,Doxycycline,(Giardiasis) Metronidazole


References:


1. American Academy of Pediatrics Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics. 2001;108:776-89. PMID:11533352
2. Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines 2006. MMWR Recomm Rep. 2006;55 (RR-11):1-94. PMID:16888612
3. Mannisto PT, Karhunen M, Koskela O et al. Concentrations of tinidazole in breast milk. Acta Pharmacol Toxicol (Copenh). 1983;53(3):254-6. PMID:6356785
4. Evaldson GR, Lindgren S, Nord CE et al. Tinidazole milk excretion and pharmacokinetics in lactating women. Br J Clin Pharmacol. 1985;19(4):503-7. PMID:4039599



Substance Identification:




Substance Name:

Tinidazole

CAS Registry Number:

19387-91-8

Drug Class:


  • Antiinfective Agents

  • Antibacterial Agents

  • Antiprotozoal Agents

  • Nitroimidazoles


  • Administrative Information:




    LactMed Record Number:


    441


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.