Tolbutamide

Drug Levels and Effects:




Summary of Use during Lactation:


Tolbutamide is excreted into breastmilk in small amounts that should cause no harm to the breastfed infant. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]


Drug Levels:


Maternal Levels.

In 2 women who were 3 days postpartum, milk levels were measured 4 hours after ingestion of a 500 mg dose of tolbutamide. Milk levels averaged 18 mg/L in one and 3 mg/L in the other.[3]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Acarbose,Chlorpropamide,Glyburide,Insulin,Metformin


References:


1. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID:9429368
2. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID:15701580
3. Moiel RH, Ryan JR. Tolbutamide Orinase in human breast milk. Clin Pediatr. 1967;8:480. PMID:6029660



Substance Identification:




Substance Name:

Tolbutamide

CAS Registry Number:

64-77-7

Drug Class:


  • Hypoglycemic Agents

  • Sulfonylurea Compounds


  • Administrative Information:




    LactMed Record Number:


    262


    Last Revision Date:


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