Tranylcypromine

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the lack of data on use during breastfeeding, other antidepressants are preferred during breastfeeding.


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Nine subjects were treated with an average dose of 29 mg daily (range10 to 40 mg) of oral tranylcypromine day for an average of 16 days. Serum prolactin levels increased by 3 mcg/L.[1]The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Alternate Drugs to Consider:


Nortriptyline,Paroxetine,Sertraline


References:


1. Price LH, Charney DS, Heninger GR. Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients. Life Sci. 1985;37:809-18. PMID:4033356



Substance Identification:




Substance Name:

Tranylcypromine

CAS Registry Number:

155-09-9

Drug Class:


  • Antidepressants

  • Monoamine Oxidase Inhibitors


  • Administrative Information:




    LactMed Record Number:


    311


    Last Revision Date:


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