Trientine

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that trientine is not detectable in breastmilk. The effect of trientine on breastmilk copper andzincconcentrations in milk is conflicting,[1][2][3] but breastfed infants appear to have normal serum copper andzincplasma levels. Based on available data, it appears that trientine is acceptable to use during breastfeeding.


Drug Levels:


Maternal Levels.

Four patients received trientine for Wilson's disease in dosages of 1000, 1500 (2 patients) and 1750 mg daily. Trientine was not detectable by HPLC in the breastmilk of any of the mothers' milk samples.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Three infants were breastfed during maternal treatment of Wilson's disease with trientine. Serumzincand copper concentrations were normal in these infants.[3]


Possible Effects on Lactation:


Conflicting data exist on breastmilk concentrations ofzincand copper during therapy of Wilson's disease with trientine. One abstract reported that breastmilk concentrations were normal during therapy,[2] but another abstract from the same authors reported lower milk concentrations ofzincand copper.[1]


Alternate Drugs to Consider:


Penicillamine


References:


1. Izumi Y. [Can mothers with Wilson's disease give her breast milk to their infant?]. Teikyo Med J. 2012;35:17-24.
2. Kaga F, Kodama H, Siga K et al. Copper andzincstatus in the breast milk of mothers with Wilson disease. J Inherit Metab Dis. 2008;31 (Suppl. 1):157. Abstract.
3. Shiga K, Kaga H, Kodama H et al. Copper andzincconcentrations in the breast milk of mothers with Wilson disease and effects on infants. J Inherit Metab Dis. 2006;29 Suppl. 1:139. Abstract.



Substance Identification:




Substance Name:

Trientine

CAS Registry Number:

112-24-3

Drug Class:


  • Chelating Agents


  • Administrative Information:




    LactMed Record Number:


    561


    Last Revision Date:


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