Vigabatrin

Drug Levels and Effects:




Summary of Use during Lactation:


Limited information indicates that maternal doses of vigabatrin up to 2000 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Until more data are available, vigabatrin should only be used with careful monitoring during breastfeeding.


Drug Levels:


Maternal Levels.

Two nursing mothers were each receiving vigabatrin 1000 mg twice daily. One was also taking slow-releasecarbamazepine200 mg twice daily. Milk samples were collected once pre-dose and 3 and 6 hours after the dose at either 6 or 8 days postpartum. In both mothers, the inactive R-isomer was excreted into milk in higher concentrations than the active S-isomer. In the 2 mothers, average concentrations of the R-isomer were 1.7 mg/L in the predose sample, 2.1 mg/L at 3 hours and 3.1 mg/L at 6 hours after the dose. Average concentrations of the S-isomer were 0.4 mg/L in the predose sample, 0.4 mg/L at 3 hours and 0.8 mg/L at 6 hours after the dose. Using peak values, the authors estimated that the maximum dosage that the infant would receive in the mothers would be 2 to 3.6% of the weight-adjusted maternal dosage for the R-isomer and 0.6 to 0.96% of the maternal dosage for the S-isomer. [1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


References:


1. Tran A, O'Mahoney T, Rey E et al. Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers. Br J Clin Pharmacol. 1998;45:409-11. PMID:9578192



Substance Identification:




Substance Name:

Vigabatrin

CAS Registry Number:

60643-86-9

Drug Class:


  • Anticonvulsants

  • GABA Agents


  • Administrative Information:




    LactMed Record Number:


    1003


    Last Revision Date:


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