Zafirlukast

Drug Levels and Effects:




Summary of Use during Lactation:


No published information is available on the use of zafirlukast during breastfeeding; however, manufacturer's data indicate that the dose in milk is low. If zafirlukast is required by the mother, it is not a reason to discontinue breastfeeding. Because there is no published experience with zafirlukast during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Zafirlukast has been used in children as young as 12 months of age.[1]


Drug Levels:


Maternal Levels.

Relevant published information was not found as of the revision date.

The manufacturer reports that after administration of zafirlukast 40 mg twice daily to lactating women (number not reported), average steady-state milk concentrations were 50 mcg/L.[2] Using these data, a fully breastfed infant would be expected to receive about 0.6% of the maternal weight-adjusted dosage.

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Beclomethasone,Cromolyn,Terbutaline,Theophylline


References:


1. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID:15701580
2. Anon. Accolate Package Insert. AstraZeneca Pharmaceuticals. Wilmington DE. July, 2004.



Substance Identification:




Substance Name:

Zafirlukast

CAS Registry Number:

107753-78-6

Drug Class:


  • Anti-Asthmatic Agents

  • Leukotriene Antagonists


  • Administrative Information:




    LactMed Record Number:


    601


    Last Revision Date:


    Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.