Zolpidem

Drug Levels and Effects:




Summary of Use during Lactation:


Because of the low levels of zolpidem in breastmilk and its short half-life, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.


Drug Levels:


Maternal Levels.

Five nursing mothers who were 3 to 4 days postpartum were given a single oral dose of zolpidem 20 mg. Milk collected 3 hours after the dose contained between 0.76 and 3.88 mcg of zolpidem. This corresponded to 0.004 to 0.019% of the maternal dosage. The drug was undetectable (<0.5 mcg/L) in milk 13 and 16 hours after the dose.[1]

Infant Levels.

Relevant published information was not found as of the revision date.


Effects in Breastfed Infants:


Relevant published information was not found as of the revision date.


Possible Effects on Lactation:


Relevant published information was not found as of the revision date.


Alternate Drugs to Consider:


Zaleplon


References:


1. Pons G, Francoual C, Guillet P et al. Zolpidem excretion in breast milk. Eur J Clin Pharmacol. 1989;37:245-8. PMID:2612539



Substance Identification:




Substance Name:

Zolpidem

CAS Registry Number:

82626-48-0

Drug Class:


  • Hypnotics and Sedatives


  • Administrative Information:




    LactMed Record Number:


    396


    Last Revision Date:


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